Homeostasis and Toxicology of Non-Essential Metals. Symptoms of arsenic poisoning, or arsenicosis, can include skin lesions, swollen limbs and loss of feeling in the hands and legs. What • Inhibits p53, Treatment of Arsenic Poisoning • Chelation therapy removes heavy metals • Dimercaprol • First antidote • Intramuscular Injection (painful) • Narrow therapeutic window • DMSA • Currently used • Fewer side effects • Can be administered orally Dimercaprol Dimercaptosuccinic acid (DMSA) Dimercaptosuccinic acid (DMSA), Summary • Symptoms include headache, drowsiness, diarrhea, vomiting, bloody urine, convulsions, changes in fingernail pigmentation • Enters body via inhalation and/or ingestion and mainly distributes to liver • Inorganic arsenate is metabolized in liver by methylation to MMA and DMA. claire m. waggoner aquatic toxicology. If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. used : rat poison found: food, water. http://dx.doi.org/10.1155/2013/219840 Sullivan, John B. and Gary R. Krieger. Long-term exposure to arsenic can also lead to cancer, possibly affecting the lungs, bladder and food air water. Dr Kaleem Khan Assistant Professor JNMCH 2. loveland tech4good luke whitaker / may 27, 2014. arsenic detection techniques. chronic arsenic poisoning among workers (17). 135 xe 10 6 b. (2011). properties. Long-term Furthermore, it was observed that new cases of human poisoning … On arrival he was pale and diaphoretic, but his vital signs were normal. Acute Poisoning: Symptoms of acute intoxication usually occur within 30 minutes of ingestion but may be delayed if arsenic is taken with the food. Arsenic. Now customize the name of a clipboard to store your clips. group 15, metalloid (category/group) germanium, gallium, it sublimates, Arsenic - . Request PDF | On Jan 1, 2000, D. N. Guha Mazumder published Chapter 4 : Diagnosis and treatment of chronic arsenic poisoning | Find, read and cite all the research you need on ResearchGate Journal of Applied Toxicology. 31:95-107. Mechanism of arsenic poisoning Adrian Bumstead, Xiao Qi Li, Jessica So, Jin (Donna) Yang PHM142 Fall 2015 Instructor: Dr. Jeffrey Henderson Overall - try to keep the text to a minimum (the presentation guideline for the cardio It acts on glycolysis, TCA cycle and on Pyruvate dehydrogenase complex. arsenic. PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. See our User Agreement and Privacy Policy. arsenic compliance in perspective water, Arsenic - . 1. The Scientific World Journal, 2013, 13 Pages. – A free PowerPoint PPT presentation (displayed as a Flash Alsevier Inc. Rosen, B. Arsenic toxicity and methods of detection. poisoning. +5. Arsenic poisoning 1. jonathan kernaghan. Arsenic is present as a contaminant in many traditional remedies. Arsenic - . 6 th period by: katelyn keller brianna leslie tiffany goulart. Arsenic toxicity and potential mechanisms of action. Stools were initially Rice water type but later became bloody
On examination he had some nail changes, sensory loss and dermatitis like picture. Arsenic Poisoning. +3. A 47-year-old man had an episode of severe respiratory failure after acute intoxication with arsenic. China lead poisoning(2009) Zamfara lead poisoning(Mar-June 2010): About 163 deaths due to illegal extraction of ore by villagers in Anka & Bukuyyum LGA’s. Arsenic is a natural semi-metallic chemical that is found all over the world in groundwater. It is highly toxic in its inorganic form.People are exposed to elevated levels of inorganic arsenic through drinking contaminated water, using contaminated water in food preparation and irrigation of food crops, industrial processes, eating contaminated food and smoking tobacco.Long-term exposure to inor… Arsenic PowerPoint Presentations you can use in your safety training programs. not anticipated! Toronto: Oxford UP, 2009. Arsenic, element 33, has a long and nefarious history; its very name has become synonymous with poison. Arsenic - . as. albertus magnus (1193-1280), a german philosopher and theologian, was the first to state that arsenic has a, Arsenic - . arsenic - . two kinds of poisoning have been identified by the national safety, Poisoning - . arsenic poisoning in tube. Arsenic poisoning: A national health security issue Arsenic exposure in Bangladesh is widespread and it involves thousands of wells. substance which when introduced into body in relatively small amounts causes in structural damage, Arsenic Rule - . Arsenic Detection Techniques - . summarized the environmental behaviour of arsenic, with particular emphasis on sources, distribution, and accumulation of arsenic in the Australianence of everyone reacts differently. Arsenic poisoning( acute, subacute and chronic) 1. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. poisoning. References Caballero, B.(2009). Patient went into shock and finally was admitted in the ICU
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. Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. Arsenic Exposure and Toxicology: A Historical Perspective Hughes, M. (2002). Customer Code: Creating a Company Customers Love, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). Metabolism • Main organ for arsenic metabolism is the liver, Metabolism continued Step 1 • Inorganic pentavalent arsenate is reduced to trivalent arsenite in the blood stream before entering the cells • Can occur non-enzymatically in the presence of a thiol such as glutathione (GSH), Metabolism continued Step 2 • Methylation to monomethylarsonic acid (MMA) and to dimethyl- arsinic acid (DMA) is enzymatic, requiring S- adenosylmethionine (SAM) and a methyltransferase • MMA and DMA are excreted in the urine (thousandfold less-potent as mutagenic agents than inorganic arsenic) • Methylation has long been considered the main route of detoxification, but there is growing literature supporting other methods such as transport and antioxidant defenses, Mechanism of Action of (As3+) • Reacts with thiol-containing molecules (R-SH) • Arsenite inhibits GSH Reductase by interacting with critical thiol groups • Blocks production of GSH (glutathione, important antioxidant) causing increased free radicals and oxidative damage • Increased production of ROS such as superoxide radical, singlet Oxygen, hydroxyl radicals, hydrogen peroxide, Mechanism of Action of (As3+) • Inhibits lipoicacid (a dithiol) which is an important cofactor for Pyruvate Dehydroxygenase (PDH) • As [Acetyl CoA] decreases  Citric Acid Cycle activity decrease, causing: • Decreased ATP production • Decreased Gluconeogenesis (synthesis of glucose from carbohydrates, fatty acids, proteins, etc) Function of PyruvateDehydroxygenase: Oxidize Pyruvate to Acetyl CoA before Citric Acid Cycle Arsenic binds to Lipoid Acid-PDH to form 6-member ring Lipoic Acid-PDH, Arsenate resembles Inorganic Phosphate Competitively inhibits phosphate for active site in G3P-Dehydroxygenase Replaces phosphate in many biochemical reactions in cellular respiration ATP ADP-arsenate (arsenolytic mechanism – uncouples ATP formation) Glucose-6-Phosphate  Glucose-6-Arsenate Glyceraldehyde-3-Phosphate  Glyceraldehyde-3-Arsenate Mechanism of Action of (As5+) Inorganic Phosphate is chemically similar to Inorganic Arsenate, Inhibition of Glyceraldehyde-3-Phosphate dehydrogenase, Arsenic is a Carcinogen • Associated with oxidative stress, cell arrest in the G2/M phase, chromosomal abnormalities, and DNA aneuploidy. 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